Research & Education

Statin Drugs: Dangers and Alternatives - Part 2

As the news surrounding the side effects and health risks of using statin medications continues to be disconcerting at best there are fortunately lots of alternatives that not only demonstrate clinical efficacy but also bring impressive health benefits.

Fish Oil

While pursuing the latest research studies on natural lipid management agents it occurred to me that some of these compounds excel at certain aspects of lipid modulation while others are exceptional at reducing other markers of lipid imbalance. For example the research demonstrates very clearly that fish oil supplementation lowers many blood lipid markers but it is especially efficient at decreasing triglycerides and the systemic inflammatory marker C-reactive protein in various recent studies under a variety of clinical settings.

 

Sources:

    1. The effect of a 12-week course of omega-3 polyunsaturated fatty acids on lipid parameters in hypertriglyceridemic adult HIV-infected patients undergoing HAART: a randomized placebo-controlled pilot trial.

    2. Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia.

    3. Effect of omega-3 fatty acids on cardiovascular risk factors in patients with type 2 diabetes mellitus and hypertriglyceridemia: an open study.

    4. Fish oil supplement alters markers of inflammatory and nutritional status in colorectal cancer patients.

    Pantethine

    Pantethine is the active methylated form of pantothenic acid and is a vastly underrated tool in the clinical setting of blood lipid modulation. It has been shown to reduce a wide range of blood lipid factors such as total cholesterol triglycerides VLDL while raising HDL levels.

    Red Yeast Rice

    Monascus pupurus or red yeast rice (RYR) is related to statin medications in that one of the primary active compounds in RYR monacolin K has the same mechanism of action as traditional statins. Additionally red yeast rice has been reported to contain sterols a class of plant based compounds known to help block the absorption of fats and cholesterol from the diet.

    It is certainly not a stretch to say that red yeast rice has been shown to be as effective as statins at lowering many markers of serum lipids while additionally lowering what is now being considered more relevant markers of cardiovascular disease lipoprotein (a) and C-reactive protein.

    Tocotrienols

    Tocotrienols along with the tocopherols are the two families that make up the complete vitamin E complex. Tocotrienols especially the delta and gamma fractions have long been touted for their cancer protective qualities and have also demonstrated particular efficacy in modulating blood lipids in particular LDL and total cholesterol.

    Designs for Health's Lipotrienols RYR is a powerful combination of natural substances intended to support normal blood lipid levels and optimize cardiac and vascular health. This unique formulation includes certified organic red yeast rice and high delta-fraction tocotrienols.

    Astaxanthin/Krill Oil

    Astaxanthin is a carotenoid compound found in the tiny shrimp-like creature krill and also in specific species of algae. It is a powerful antioxidant that has also been shown to possess various beneficial therapeutic properties including applications in cognitive health sports recovery cancer prevention PMS and also cardiovascular health.  Astaxanthin has been shown to significantly reduce LDL cholesterol and triglycerides while raising HDL and mitigating the progression of atherosclerosis. 

    Vitamin B3/Niacin

    Finally the use of vitamin B3 (Niacin) has for many years been a standard of care regarding lipid modulation as its use has consistently shown efficacy in balancing multiple blood lipid parameters especially increasing HDL and lowering lipoprotein(a) while also improving endothelial function and reducing atherosclerosis.  

    Whether or not one fully embraces the cholesterol theory of cardiovascular disease is one thing. For those that feel that cholesterol reduction is an important clinical and therapeutic goal there are fortunately many natural substances that can be used to obtain outstanding clinical results while improving metabolic risk factors which include inflammation atherosclerosis and certain important lipid blood markers minus the myriad of unwanted side effects associated with statin medications.

    Click Here to Read: Statin Drugs: Dangers and Alternatives - Part 1