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Delayed reporting of concussions may lead to prolonged post-concussion symptoms

According to a study published in this month’s Journal of Athletic Training, athletes who wait to report a concussion may experience prolonged recovery times. Researchers determined that athletes who delay post-concussion treatment missed close to one more week of activity than those who received immediate treatment. Athletes who do not receive immediate treatment are at risk for further damage to the brain and will most likely take much longer to recover. Previous research has also supported...Read more

DHA helps improve kidney cancer therapy according to new study

According to a new study published in the journal Molecular Cancer Therapeutics, researchers demonstrate that docosahexaenoic acid (DHA) helps reduce renal cell carcinoma invasiveness, growth rate, and blood vessel growth when combined with the anti-cancer therapy regorafenib.  Regorafenib is one of a new generation of anti-cancer therapies that attack tyrosine kinases. Unfortunately, kidney cancers mutate to resist these therapies. However, DHA metabolites called...Read more

Study demonstrates nutritional supplements improve efficacy of antidepressants

According to an evidence review published earlier this week in the American Journal of Psychiatry, researchers confirmed that certain nutritional supplements can increase the efficacy of antidepressants for individuals with clinical depression. Researchers at Harvard and the University of Melbourne examined 40 clinical trials along with a systematic review of the evidence for nutrient supplements that are used as adjuncts to help with clinical depression. As a result, fish oil, SAMe,...Read more

New study finds vitamin D improves heart function

According to a new study published Monday in the Journal of the American College of Cardiology, researchers demonstrated that vitamin D improves heart function in patients with chronic heart failure. Heart failure affects more than 23 million people worldwide. This statistic emphasizes the significance of this new study because it presents the first evidence that vitamin D supplementation can improve heart function of people with heart failure. The findings could make a meaningful difference in...Read more

New study shows higher doses of omega 3 fatty acids, specifically EPA, are beneficial for depression

Depression is a major cause of disease burden worldwide, affecting approximately 350 million people. For quite some time now, fish oil supplementation has been a recommended adjunct for helping with major depressive disorder (MDD). According to a new meta-analysis published two weeks ago in Translational Psychiatry, researchers have further confirmed the link between intake of omega-3 fatty acids and the reduction in major depressive disorder. This meta-analysis consisted of 13...Read more

New study reveals individuals with metabolic syndrome may require more vitamin E

New research published just two days ago in the American Journal of Clinical Nutrition demonstrated that approximately one-third of Americans who have metabolic syndrome do not absorb dietary vitamin E as effectively as healthy individuals. Vitamin E is a potent antioxidant that is essential to overall health. It is estimated that 35% of Americans have metabolic syndrome, which is characterized by having at least three of the following traits: excess abdominal fat, elevated blood pressure, low...Read more

Chemical exposure may be linked to rising rates in diabetes and obesity

According to a statement issued three days ago by the Endocrine Society, their summary links endocrine-disrupting chemical exposure to two of our biggest public health risks, diabetes and obesity. This news builds upon the Endocrine Society’s 2009 report, which examined the scientific evidence on endocrine-disrupting chemicals (EDCs) and the health risks associated with them. Since 2009, additional research has demonstrated that exposure to EDCs is associated with an increased risk of diabetes...Read more

Low vitamin D associated with age-related cognitive decline and dementia

In a new study published earlier this month in JAMA Neurology, researchers demonstrated a significant association between vitamin D insufficiency and cognitive decline that is specifically seen in Alzheimer's disease and dementia. The results reinforce the importance of identifying vitamin D insufficiency among the elderly. Here, low vitamin D levels were associated with significantly faster rates of decline in memory and executive function performance. This study included approximately...Read more

Resveratrol helps to stabilize Alzheimer's disease biomarker

A new study published last week in the journal Neurology demonstrated that long-term, high-dose resveratrol stabilized amyloid-beta40 (Abeta40) in patients with mild to moderate Alzheimer's disease. This biomarker declines when the disease progresses. Even though this is a single, small study, it is the largest and longest nationwide human clinical trial of high-dose resveratrol to date. The clinical trial was a randomized, phase II, placebo-controlled, double blind study in patients with mild...Read more

New study finds high prevalence of pre-diabetes and diabetes in the U.S.

According to a new study published in JAMA just three days ago, the increasing prevalence of diabetes may be leveling off. That being said, in 2011 through 2012, the estimated prevalence of diabetes among U.S. adults was 14% and the prevalence of pre-diabetes was 38%, which means about half of the U.S. adult population has either diabetes or pre-diabetes. Diabetes is a major cause of illness and death and is still a significant problem in the U.S. The healthcare costs associated with diabetes...Read more

Vitamin D and its role in macular degeneration

Vitamin D has been extensively researched for its benefits in bone health, cancer, inflammation, and the immune system. A new study published in JAMA Ophthalmology last week found that vitamin D may be a critical player in eye health in the prevention of age-related macular degeneration, specifically among women who are genetically susceptible. This may have to do with its role in inflammation, which is believed to be involved in the development of macular degeneration. Macular...Read more

Are you allergic to the fruits and vegetables you eat? You may actually be reacting to the antibiotic residues in the food.

A recent article published in Annals of Allergy, Asthma and Immunology discusses a case of a 10 year-old girl who had an anaphylactic reaction after eating blueberry pie. She had a history of asthma and seasonal allergies, and known allergies to penicillin and cow's milk, but she was not aware of being allergic to any of the ingredients in the pie. After much testing, it was discovered that the reaction was caused by streptomycin-contaminated blueberry. Streptomycin is a well-known antibiotic,...Read more

Green tea polyphenols protect spinal cord neurons against oxidative stress

Green tea polyphenols are a potential new aid for the recovery and regeneration of neurons after spinal cord injury. Several factors contribute to pathological changes secondary to spinal cord injury, with oxidative stress having a very important role. The formation of reaction oxygen species is the basic response to disease and trauma that contributes significantly to the injury. As a result, oxidative stress and inflammation cause the death of neurons and are the main processes leading to...Read more

Can probiotics help prevent obesity?

In a recent study, researchers at Vanderbilt tested a bacteria that can produce a “therapeutic compound” in the gut. The results showed that it stopped weight gain, insulin resistance and other health complications.  Past research has demonstrated that gut bacteria plays a role in the development of obesity, diabetes, and cardiovascular disease.  According to Sean Davis, PhD, assistant professor of pharmacology at Vanderbilt, “The types of bacteria you have in your gut influence your...Read more

Is niacin safe?

There has been some recent negative news about niacin based on the HPS2-THRIVE study, and now we see it again, this time in the New England Journal of Medicine.  Let’s take a closer look at all of this.  First, in the recent HPS2-THRIVE study, which examined an investigational drug from Merck, the researchers state that niacin does not provide any benefits. The drug they looked at is a combination of extended-release niacin and laropiprant, a drug which partially blocks the flushing...Read more

Examining immune-related disorders and microbial balance

It has become increasingly clear that many diseases are triggered or influenced by changes in bacterial populations in the gut. The general view up until now has been that bacteria stimulate the immune system, which leads to inflammation or autoimmune diseases. In a recent study published in Immunity, researchers have painted a more complex picture. The immune system of the gastrointestinal tract not only prevents the invasion of pathogens, but it is more actively involved in the balance...Read more

The human gut has only a limited ability to convert folic acid to 5-MTHF.

There has been a lot of press on the link between MTHFR (methylenetetrahydrofolate reductase) gene mutations and chronic disease. This has resulted in a great deal of concern with the particular form of folate that doctors are giving to their patients. As Director of Clinical and Product Support here at Designs for Health, I personally speak to approximately five doctors a day about this very topic. According to a recent study in the American Journal of Clinical Nutrition, the human gut appears...Read more

Researchers discover changes in intestinal barrier function in patients with multiple sclerosis

Posted on Fri, Sep 12, 2014 @ 12:23 PM

intestineResearchers in Sweden at Lund University published new research on the role of the intestinal barrier in the autoimmune disease multiple sclerosis (MS). This study investigated whether intestinal function is also attacked in MS, as the researchers demonstrated that inflammation and changes in the intestinal barrier function occur early on in the course of the disease.

Scientists at Lund University have previously shown that probiotics could provide a certain amount of protection against MS. Therefore, they questioned whether the intestinal barrier was affected, which led to their examination of inflammatory cells and processes in the intestine. As a result, they saw structural changes in the gastrointestinal mucosa of the small intestine and an increase in inflammatory T-cells. In addition, they saw a reduction in regulatory T-cells (immunosuppressive cells). These changes are often linked to inflammatory bowel diseases.

“In most cases, we don’t know what triggers autoimmune diseases, but we know that pathogenic cells frequent and disrupt the intestines. A leaky gut enables harmful bacteria and toxic substances in the body to enter the intestine, which creates even more inflammation. Our findings provide support for the idea that a damaged intestinal barrier can prevent the body ending an autoimmune reaction in the normal manner, leading to a chronic disease such as MS”, said Dr. Shahram Lavasani, one of the study’s authors.

Dr. Lavasani and his colleagues believe that future drugs to treat MS should not only focus on the central nervous system, but also on repairing and restoring the intestinal barrier. They hope for the development of a better treatment that looks at the intestinal barrier as a new therapeutic target.

This is a perfect example of the big disconnect between medical research, which is often outstanding, and the practice of traditional medicine, which often leaves quite a bit to be desired when it comes to the management  of chronic disorders.

If we know what causes the immune system to attack itself and we know some of the triggers for what causes a malfunction in the immune system – which we do – we can successfully treat these conditions.

Autoimmunity can occur several different ways. First, there can be a mistaken identity and the body attacks itself. This can occur with a virus where there is tissue destruction and it appears foreign to the body. This can also happen with heavy metal toxicities such as mercury. The second way is called molecular mimicry. This occurs when the body makes an antibody (a protein in the body that attacks objects in the body that appear to be foreign) to a specific antigen. These antigens can resemble certain proteins in the body and the antibodies attack our body’s own tissues. Third is the development of the T cells (the immune system). This can be affected by genetics, stress and environmental triggers. Environmental triggers are what integrative doctors often work with in functional medicine. What appears to happen with most autoimmune conditions is there are multiple triggers chronically stimulating the immune system over a long period of time in multiple ways. Our immune system gets into an overloaded, overwhelmed state and loses its ability to function.

There are many autoimmune diseases within all specialties and all of these are looked at differently.  However, they all have the same common triggers as demonstrated in this study. Therefore, it seems appropriate that we can take a similar approach in treating all autoimmune conditions.

 

Source: Intestinal Barrier Dysfunction Develops at the Onset of Experimental Autoimmune Encephalomyelitis, and Can Be Induced by Adoptive Transfer of Auto-Reactive T Cells. Mehrnaz Nouri, Anders Bredberg, Björn Weström, Shahram Lavasani. Published: September 03, 2014. DOI: 10.1371/journal.pone.0106335 

 

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Tags: Autoimmunity, Multiple Sclerosis

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