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Delayed reporting of concussions may lead to prolonged post-concussion symptoms

According to a study published in this month’s Journal of Athletic Training, athletes who wait to report a concussion may experience prolonged recovery times. Researchers determined that athletes who delay post-concussion treatment missed close to one more week of activity than those who received immediate treatment. Athletes who do not receive immediate treatment are at risk for further damage to the brain and will most likely take much longer to recover. Previous research has also supported...Read more

DHA helps improve kidney cancer therapy according to new study

According to a new study published in the journal Molecular Cancer Therapeutics, researchers demonstrate that docosahexaenoic acid (DHA) helps reduce renal cell carcinoma invasiveness, growth rate, and blood vessel growth when combined with the anti-cancer therapy regorafenib.  Regorafenib is one of a new generation of anti-cancer therapies that attack tyrosine kinases. Unfortunately, kidney cancers mutate to resist these therapies. However, DHA metabolites called...Read more

Study demonstrates nutritional supplements improve efficacy of antidepressants

According to an evidence review published earlier this week in the American Journal of Psychiatry, researchers confirmed that certain nutritional supplements can increase the efficacy of antidepressants for individuals with clinical depression. Researchers at Harvard and the University of Melbourne examined 40 clinical trials along with a systematic review of the evidence for nutrient supplements that are used as adjuncts to help with clinical depression. As a result, fish oil, SAMe,...Read more

New study finds vitamin D improves heart function

According to a new study published Monday in the Journal of the American College of Cardiology, researchers demonstrated that vitamin D improves heart function in patients with chronic heart failure. Heart failure affects more than 23 million people worldwide. This statistic emphasizes the significance of this new study because it presents the first evidence that vitamin D supplementation can improve heart function of people with heart failure. The findings could make a meaningful difference in...Read more

New study shows higher doses of omega 3 fatty acids, specifically EPA, are beneficial for depression

Depression is a major cause of disease burden worldwide, affecting approximately 350 million people. For quite some time now, fish oil supplementation has been a recommended adjunct for helping with major depressive disorder (MDD). According to a new meta-analysis published two weeks ago in Translational Psychiatry, researchers have further confirmed the link between intake of omega-3 fatty acids and the reduction in major depressive disorder. This meta-analysis consisted of 13...Read more

New study reveals individuals with metabolic syndrome may require more vitamin E

New research published just two days ago in the American Journal of Clinical Nutrition demonstrated that approximately one-third of Americans who have metabolic syndrome do not absorb dietary vitamin E as effectively as healthy individuals. Vitamin E is a potent antioxidant that is essential to overall health. It is estimated that 35% of Americans have metabolic syndrome, which is characterized by having at least three of the following traits: excess abdominal fat, elevated blood pressure, low...Read more

Chemical exposure may be linked to rising rates in diabetes and obesity

According to a statement issued three days ago by the Endocrine Society, their summary links endocrine-disrupting chemical exposure to two of our biggest public health risks, diabetes and obesity. This news builds upon the Endocrine Society’s 2009 report, which examined the scientific evidence on endocrine-disrupting chemicals (EDCs) and the health risks associated with them. Since 2009, additional research has demonstrated that exposure to EDCs is associated with an increased risk of diabetes...Read more

Low vitamin D associated with age-related cognitive decline and dementia

In a new study published earlier this month in JAMA Neurology, researchers demonstrated a significant association between vitamin D insufficiency and cognitive decline that is specifically seen in Alzheimer's disease and dementia. The results reinforce the importance of identifying vitamin D insufficiency among the elderly. Here, low vitamin D levels were associated with significantly faster rates of decline in memory and executive function performance. This study included approximately...Read more

Resveratrol helps to stabilize Alzheimer's disease biomarker

A new study published last week in the journal Neurology demonstrated that long-term, high-dose resveratrol stabilized amyloid-beta40 (Abeta40) in patients with mild to moderate Alzheimer's disease. This biomarker declines when the disease progresses. Even though this is a single, small study, it is the largest and longest nationwide human clinical trial of high-dose resveratrol to date. The clinical trial was a randomized, phase II, placebo-controlled, double blind study in patients with mild...Read more

New study finds high prevalence of pre-diabetes and diabetes in the U.S.

According to a new study published in JAMA just three days ago, the increasing prevalence of diabetes may be leveling off. That being said, in 2011 through 2012, the estimated prevalence of diabetes among U.S. adults was 14% and the prevalence of pre-diabetes was 38%, which means about half of the U.S. adult population has either diabetes or pre-diabetes. Diabetes is a major cause of illness and death and is still a significant problem in the U.S. The healthcare costs associated with diabetes...Read more

Vitamin D and its role in macular degeneration

Vitamin D has been extensively researched for its benefits in bone health, cancer, inflammation, and the immune system. A new study published in JAMA Ophthalmology last week found that vitamin D may be a critical player in eye health in the prevention of age-related macular degeneration, specifically among women who are genetically susceptible. This may have to do with its role in inflammation, which is believed to be involved in the development of macular degeneration. Macular...Read more

Are you allergic to the fruits and vegetables you eat? You may actually be reacting to the antibiotic residues in the food.

A recent article published in Annals of Allergy, Asthma and Immunology discusses a case of a 10 year-old girl who had an anaphylactic reaction after eating blueberry pie. She had a history of asthma and seasonal allergies, and known allergies to penicillin and cow's milk, but she was not aware of being allergic to any of the ingredients in the pie. After much testing, it was discovered that the reaction was caused by streptomycin-contaminated blueberry. Streptomycin is a well-known antibiotic,...Read more

Green tea polyphenols protect spinal cord neurons against oxidative stress

Green tea polyphenols are a potential new aid for the recovery and regeneration of neurons after spinal cord injury. Several factors contribute to pathological changes secondary to spinal cord injury, with oxidative stress having a very important role. The formation of reaction oxygen species is the basic response to disease and trauma that contributes significantly to the injury. As a result, oxidative stress and inflammation cause the death of neurons and are the main processes leading to...Read more

Can probiotics help prevent obesity?

In a recent study, researchers at Vanderbilt tested a bacteria that can produce a “therapeutic compound” in the gut. The results showed that it stopped weight gain, insulin resistance and other health complications.  Past research has demonstrated that gut bacteria plays a role in the development of obesity, diabetes, and cardiovascular disease.  According to Sean Davis, PhD, assistant professor of pharmacology at Vanderbilt, “The types of bacteria you have in your gut influence your...Read more

Is niacin safe?

There has been some recent negative news about niacin based on the HPS2-THRIVE study, and now we see it again, this time in the New England Journal of Medicine.  Let’s take a closer look at all of this.  First, in the recent HPS2-THRIVE study, which examined an investigational drug from Merck, the researchers state that niacin does not provide any benefits. The drug they looked at is a combination of extended-release niacin and laropiprant, a drug which partially blocks the flushing...Read more

Examining immune-related disorders and microbial balance

It has become increasingly clear that many diseases are triggered or influenced by changes in bacterial populations in the gut. The general view up until now has been that bacteria stimulate the immune system, which leads to inflammation or autoimmune diseases. In a recent study published in Immunity, researchers have painted a more complex picture. The immune system of the gastrointestinal tract not only prevents the invasion of pathogens, but it is more actively involved in the balance...Read more

The human gut has only a limited ability to convert folic acid to 5-MTHF.

There has been a lot of press on the link between MTHFR (methylenetetrahydrofolate reductase) gene mutations and chronic disease. This has resulted in a great deal of concern with the particular form of folate that doctors are giving to their patients. As Director of Clinical and Product Support here at Designs for Health, I personally speak to approximately five doctors a day about this very topic. According to a recent study in the American Journal of Clinical Nutrition, the human gut appears...Read more

Bacteria invading the gut linked to diabetes according to new study

Posted on Fri, Jun 02, 2017 @ 06:38 PM

Alterations in gut microbiome have been associated with metabolic diseases such as obesity and type 2 diabetes; however, the changes in bacteria species or genomic composition are not clear. Previous animal studies have indicated that bacteria that are able to invade the epithelium may cause inflammation that drives metabolic disorders.

According to a new study published in the journal Cellular and Molecular Gastroenterology and Hepatology, researchers at Georgia State University have identified a correlation between bacteria invading the intestinal epithelium of the colon and the development of type 2 diabetes.

In this study, researchers used samples from patients at the Veteran's Administration Hospital in Atlanta. These individuals were at least 21 years old with no other health issues other than diabetes. They all had a colonoscopy in which two mucosal biopsies from the left colon were analyzed.

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Tags: Diabetes, microbiome, gut health

New study demonstrates differences in the gut microbiota and regions of the brain in IBS

Posted on Fri, May 12, 2017 @ 10:01 AM

According to a new study published on May 1st, UCLA researchers identified a relationship between the gut microorganisms and brain volume in those with irritable bowel syndrome (IBS).

This is the first time researchers have been able to show an association between the gut microbiota and regions of the brain involved in sensory information processing in patients with IBS. These results suggest that signals from the brain can influence the composition of gut microbes and also that the chemicals in the intestine can shape the structure of the brain.

Previous animal studies have demonstrated effects of gut microbiome on brain function and behavior as well as the influence of the brain on the composition of microbes in the gut. That being said, only one human study has confirmed these findings.

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Tags: brain health, Inflammation, microbiota, inflammatory bowel disease, gut health

New study demonstrates effect of dietary supplements on clinical aspects of autism

Posted on Fri, Apr 28, 2017 @ 01:42 PM

Autism spectrum disorder (ASD) has an unclear cause but is associated with various genetic, neurologic, metabolic, and immunologic factors. Although there is no definitive treatment, there has been increasing use of dietary interventions and nutritional support in these patients. For example, many children with ASD take nutritional supplements and follow specific diets such as a gluten-free and casein-free (GFCF) diet.

Pharmaceutical and behavioral therapies are often used, but their success is limited. This can be due to the high variability of autism as well as adverse reactions to medications.

According to a review published seven days ago in Brain Development, researchers demonstrated the clinical efficacy and safety of dietary supplements in children with autism.

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Tags: supplements, Vitamin C, autism, vitamin d, children's health, gut health, autism spectrum disorder, essential fatty acids

New study demonstrates bovine colostrum decreases intestinal permeability in athletes

Posted on Fri, Apr 14, 2017 @ 07:57 AM

An interesting study was just published 6 days ago in Nutrients on intestinal permeability and athletes. This is a compelling follow-up to a similar article I shared last July in the American Journal of Clinical Nutrition on heavy exercise-induced intestinal permeability in athletes.

When one thinks of nutritional supplements in athletes, they usually think of nutrients that enhance energy and sports performance. However, athletes commonly suffer from gut issues that are often not identified or addressed. 'Leaky gut' occurs from dysfunction in the intestinal barrier. This intestinal barrier in the gut is only one cell layer thick. It is essential for the absorption of nutrients and preventing large molecules and bacteria from getting into the blood stream. This is a particular problem for those taking part in heavy exercise or any form of vigorous strength training, such as CrossFit athletes, strongman competitors, and powerlifters, and can lead to gut issues in athletes as well as more serious conditions such as inflammatory bowel and autoimmune disorders.

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Tags: exercise, gut health, leaky gut

New study investigates potential mechanisms of serum-derived bovine immunoglobulin in patients with IBS

Posted on Fri, Mar 31, 2017 @ 09:30 AM

Irritable bowel syndrome (IBS) is a condition consisting of cramping, abdominal pain, bloating, gas, diarrhea and constipation. IBS is often debilitating and can affect many aspects of a person’s life, including their work, sleep and relationships.

A variety of factors have been associated with IBS, such as genetic susceptibility, infections, small bowel intestinal overgrowth, deficiencies in tight junction proteins, intestinal abnormalities with bile acid metabolism, changes in GI motility, visceral hypersensitivity, dysregulation of the interaction between the CNS and enteric nervous system, and even psychosocial factors.

An individual with IBS may need a combination of botanicals, enzymes, and probiotics to optimize the gastrointestinal environment. Certain diagnostic tests may also be beneficial, including stool testing as well as food antibody testing.

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Tags: IBD, Inflammation, inflammatory bowel disease, gut health

New study links inflammation and changes in the gut microbiome to type I diabetes

Posted on Thu, Jan 26, 2017 @ 10:08 PM

There has been a significant increase in the incidence of autoimmune disorders over the past several decades. Currently, for every 1,000 Americans, between one and five people have type 1 diabetes. Type 1 diabetes typically develops when the body's own immune system attacks the pancreas and prevents the production of insulin.

There has been increasing evidence of the correlation between the gut and type I diabetes. Alessio Fasano, MD brought this to everyone’s attention in his article, “Surprises from Celiac Disease” (Scientific American, August 2009), where he discussed the role of zonulin in intestinal permeability and in many autoimmune diseases such as celiac disease, type I diabetes, MS, and rheumatoid arthritis.

Now, according to a study published last week in the Journal of Clinical Endocrinology & Metabolism, researchers demonstrated that patients with type 1 diabetes exhibit a specific inflammatory profile and microbiome composition that are different from healthy individuals (as well as from those with other autoimmune conditions), suggesting the gut’s potential role in the development of type I diabetes.

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Tags: Diabetes, Inflammation, autoimmune disease, microbiome, gut health, type I diabetes

New study demonstrates the gut-brain relationship with irritable bowel syndrome

Posted on Thu, Jul 28, 2016 @ 04:37 PM

New research published last Friday in the Alimentary Pharmacology & Therapeutics demonstrated that there is a distinct brain-gut pathway (psychological symptoms begin first) as well as a separate gut-brain pathway (gut symptoms begin first) as seen in patients with irritable bowel syndrome (IBS). IBS can be a debilitating condition consisting of cramping, abdominal pain, bloating, gas, diarrhea and constipation. It can affect and one’s work, sleep and relationships. 

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Tags: IBS, GI Health, gut health

Heavy exercise induced intestinal permeability: New study suggests gut support for athletes

Posted on Thu, Jul 07, 2016 @ 12:45 PM

There was an interesting article published last week in The American Journal of Clinical Nutrition regarding heavy exercise induced intestinal permeability in athletes. When one thinks of nutritional supplements for athletes, they usually think of nutrients that increase or enhance energy and sports performance. However, athletes commonly suffer from gut issues that are often not identified or addressed. 'Leaky gut' occurs from dysfunction in the intestinal barrier. This intestinal barrier in the gut is only one cell layer thick. It is essential for the absorption of nutrients and for preventing large molecules and bacteria from getting into the blood stream.

Read More

Tags: Nutrients, gut health, leaky gut

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