Science Update

New study demonstrates curcuminoids increase HDL and lower lipoprotein(a) in type 2 diabetes patients


There are only a few natural products that have demonstrated such a wide range of protective properties as curcumin. Turmeric has three main bioactive components namely curcumin desmethoxycurcumin and bisdemethoxycurcumin. These curcuminoids have many biological effects including anti-inflammatory antioxidant antitumor antibacterial and antiviral properties.

According to a new study published last month in Complementary Therapies in Medicine another application can be added to this list: addressing dyslipidemia in patients with type II diabetes. Researchers demonstrated that curcuminoid supplementation can reduce lipoprotein(a) and increase HDL-C which may reduce the risk of a cardiovascular event in these patients. 

This study included a total of 82 patients with type II diabetes 18 to 65 years of age. Each patient took either 1000 mg of standardized curcumin or a placebo for 12 weeks. Baseline lab testing included serum triglycerides total cholesterol HDL-C non-HDL-C and lipoprotein(a). At the end of the 12 weeks there was a significant reduction of serum lipoprotein(a) and an increase in HDL-C concentrations only seen in the curcuminoid group. There were no significant changes in total cholesterol LDL-C and triglycerides in either group.

This is an interesting study since the ability to influence liporotein(a) is very limited. Niacin is one of the only natural agents that can significantly reduce liporotein(a); however it is not effective for everyone.

Health care providers have many tools today to assess cardiovascular health and support the bodys physiology and it is essential to perform a thorough assessment of these patients. This may include looking at lipid fractionation profiles chronic inflammatory markers (ferritin hs-CRP fibrinogen) nutrient markers (magnesium potassium selenium copper folate B12 B6 zinc and calcium) fat soluble nutrients (vitamins A D E & K and CoQ10) oxidative stress factors (homocysteine insulin and lipid peroxidases) heavy metals and fatty acid profiles. A successful treatment approach should include investigation into these various factors.

By Michael Jurgelewicz DC DACBN DCBCN CNS

Source: Panahi Y Khalili N et al. Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized control trial. Complementary Therapies in Medicine. 2017 August;22:1-5. doi: 10.1016/j.ctim.2017.05.006.